Quadruple Ultra-low-dose Treatent for Hypertension

This study is now CLOSED

QUARTET may change the way high blood pressure is managed in persons with hypertension


Hypertension is common, and while many sufferers receive some treatment, most do not achieve blood pressure control. Evidence suggests that low dose blood pressure lowering combination therapy could achieve better and quicker BP control with less side-effects than current guideline recommended approaches. Combining different medicines into a single pill simplifies treatment and is likely to improve long-term adherence. Quartet is an initiative of The University of Sydney of Global Health in Sydney. The University of Sydney is a leading cardiovascular research centre in Australia and the CCRE at Curtin University is a strategic partner.

This clinical trial will determine if treatment with a combination pill of four blood pressure lowering medications at ultra-low doses will lower blood pressure more effectively, with fewer side-effects compared to a standard dose of an individual drug (called monotherapy). QUARTET will also determine the cost-effectiveness of this treatment. 

QUARTET may change the way high blood pressure is managed in persons with hypertension, leading to better outcomes and improvements in clinical practice. This will pave the way for the development of similar products in other chronic disease conditions.  The trial length is 3 months.

Register your interest
We are looking for participants to take part in this study. To be eligible you must meet the following criteria:

  1. Be over 18 years of age
  2. Currently have high blood pressure (hypertension)
  3. Either be on no medication at all, or only one medication for treatment of high blood pressure

If you think you satisfy the inclusion criteria then please use the “Register Your Interest” button above or call 1800 971 022 and ask to speak with the QUARTET Study Co-ordinator.

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Centre for Clinical Research and Education
Address: School of Population Health, Curtin University, Bentley WA 6102